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pentobarbital will lessen the extent or result of larotrectinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lower the level or effect of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not recommended; potent cytochrome P450 enzyme inducers reduce systemic p